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One of the main limitations in liquid chromatography today is still the significant extra-column volume contribution of commercial chromatographic systems to band broadening. I believe that current instruments have reached their limits and therefore one might expect some completely new integrated system designs (for example, a slot for the column, on-column injection and on-column detection) alongside developments of column technology.
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This article describes the analytical challenges of chemical exposomics in food safety. The need for high-throughput, multi-platform approaches—such birli LC–HRMS and GC–HRMS with IMS—to capture the full spectrum of potential contaminants in our food supply is emphasized.
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Daniel Armstrong başmaklık very recently illustrated the possibility to perform sub-second separations using 5-mm long columns on current instrumentation. For such applications it could make sense to further improve